The sense of taste has strong sociocultural and emotional significance. When patients experience taste dysfunction because of cancer or its treatment, negative effects such as decreased food consumption, poor appetite, and early satiety can occur, resulting in weight loss and altered nutrition.
As many as 60% of pediatric patients with cancer receiving chemotherapy report experiencing chemotherapy-induced nausea and vomiting. The side effect has both physical and psychosocial effects, including anorexia, malnutrition, fluid and electrolyte imbalances, poor functional status, and anxiety.
One of the most frustrating side effects of chemotherapy for patients is chemotherapy-related cognitive impairment. As many as 83% of breast cancer survivors report some degree of cognitive changes after chemotherapy treatment.
Pazopanib is an oral therapy that is approved to treat advanced renal cell carcinoma. It also exhibits activity against melanoma and breast, prostate, colon, and lung cancers, although it has not yet been approved for use in those cancers. The drug specifically targets the tyrosine kinase receptor but also works against vascular endothelial growth factor receptor, platelet-derived growth factor receptor, and c-Kit.
Symptoms of lung cancer rarely occur in isolation. Rather, most patients experience a range of symptoms, from fatigue to cough, dyspnea, anorexia, pain, and insomnia. Although these groups of symptoms, or symptom clusters, have been studied in the past, research to date has not focused on the symptom experience of women with advanced lung cancer specifically.